OPKO Health, Inc.

OPKUS

OPKO Health, Inc. operates as a healthcare enterprise with a dual focus on diagnostics and pharmaceuticals. Its operations span the United States, Ireland, Chile, Spain, Israel, Mexico, and other international markets. The company's Diagnostics division encompasses BioReference Laboratories, which delivers a comprehensive suite of laboratory testing services. These services are crucial for disease detection, diagnosis, evaluation, monitoring, and treatment, covering areas such as esoteric testing, molecular diagnostics, anatomical pathology, genetics, women's health, and correctional healthcare. BioReference serves a diverse client base, including medical practices, clinics, hospitals, employers, and government entities. Additionally, this segment provides a cutting-edge diagnostic instrument system designed for immediate, point-of-care blood test results, alongside its specialized 4Kscore testing for prostate cancer. Within the Pharmaceutical segment, OPKO offers a range of therapeutic products and a robust development pipeline. Key offerings include Rayaldee, indicated for the management of secondary hyperparathyroidism in adults suffering from stage 3 or 4 chronic kidney disease and vitamin D insufficiency. The pipeline features OPK88004, an investigational orally administered selective androgen receptor modulator; OPK88003, a peptide administered once weekly currently in Phase IIb trials for the treatment of type 2 diabetes and obesity; and hGH-CTP, a once-weekly human growth hormone injection that has successfully completed Phase III clinical trials in collaboration with Pfizer, Inc. A core strategy for this segment involves the development and commercialization of proprietary, extended-release versions of existing therapeutic proteins. Furthermore, OPKO Health supplies specialty active pharmaceutical ingredients (APIs) and is involved in the development, manufacturing, marketing, and sale of pharmaceutical, nutraceutical, veterinary, and ophthalmic products. The company also commercializes food supplements and over-the-counter products, produces and sells items primarily within the generics market, and handles the import, marketing, distribution, and sales of pharmaceutical products across various therapeutic areas, including cardiovascular conditions, vaccines, antibiotics, gastro-intestinal ailments, and hormone-related treatments, among others. Its pharmaceutical operations are further bolstered by platforms situated in Ireland, Chile, Spain, and Mexico. Founded in 1991, OPKO Health, Inc. maintains its corporate headquarters in Miami, Florida.

Founded1991IPO year1995As of2026-08-04
Market Cap
$970M
Enterprise Value
$1.06B
EV / LTM Revenue
1.7x
EV / NTM Revenue
1.8x
Trading multiples

Enterprise value over trailing (LTM) vs. forward (NTM) fundamentals. Click an LTM cell to chart it.

LTM
trailing
NTM
forward
Revenue
1.8x
Gross Profit
5.9x
EBITDA
Classification
Sector
Healthcare Services
Sub-sector
Diagnostics & Clinical Services
Listing
OPK
Country
US
Historical valuation & fundamentals

EV / LTM Revenue

Annual financials & analyst forecasts

$MCY2021CY2022CY2023CY2024CY2025CY2026ECY2027E
Revenue YoY-43%-14%-17%-15%-6%3%
Revenue$1.77B$1.00B$863M$713M$607M$570M$589M
Gross Profit$582M$288M$318M$219M$128M
Gross Profit Margin32.8%28.7%36.8%30.6%21.1%
EBITDA$84M($271M)($66M)$135M($41M)($20M)($21M)
EBITDA Margin4.7%-27.0%-7.6%19.0%-6.8%-3.5%-3.5%
EBIT$19M($226M)($157M)($152M)($219M)($84M)($87M)
Net Income($30M)($328M)($189M)($53M)($226M)($162M)($219M)
Free Cash Flow$6M($120M)($44M)($208M)($191M)
FCF Margin0.3%-11.9%-5.2%-29.2%-31.4%
Short-Term Debt$29M$51M$27M$15M$23M
Long-Term Debt$190M$219M$222M$422M$371M
Cash & Cash Equivalents$135M$153M$96M$432M$369M
Net Debt$84M$117M$153M$5M$24M
Net Debt / EBITDA1.0x0.0x
Rule of 40-55.3%-19.2%-46.6%-46.3%
Figures in $M. True calendar years (Jan–Dec) built from quarterly data — income & cash-flow lines summed across the four quarters, balance sheet as of year-end. E columns are calendarized analyst consensus — gross profit, cash flow and balance-sheet lines are not estimated. Net debt = short-term debt + long-term debt − cash & cash equivalents; Rule of 40 = YoY revenue growth + FCF margin.