Lantheus Holdings, Inc.

LNTHUS

Lantheus Holdings, Inc. is a global pharmaceutical company dedicated to the development, manufacturing, and commercialization of advanced diagnostic and therapeutic agents. Their mission is to empower clinicians worldwide in the accurate diagnosis and effective treatment of a wide spectrum of conditions, particularly heart disease, various cancers, and other serious illnesses. Their current diagnostic portfolio features several key products: DEFINITY, a microbubble ultrasound contrast agent for cardiac evaluations; TechneLite, a technetium generator essential for nuclear medicine; Xenon-133, used to assess pulmonary function; Neurolite, which helps identify stroke-damaged areas in the brain; Cardiolite, an injectable Tc-99m-labeled imaging agent; Thallium-201 for detecting cardiovascular disease; and Gallium-67, utilized in identifying infections and cancerous tumors. They also offer the Automated Bone Scan Index, a tool for quantifying prostate cancer burden from bone scans; PYLARIFY, designed for visualizing lymph nodes, bone, and soft tissue metastases to detect recurrent or metastatic prostate cancer; and Cobalt (Co 57), a non-pharmaceutical radiochemical. In the therapeutic space, Lantheus provides AZEDRA, a radiopharmaceutical treatment for both adult and pediatric patients, and RELISTOR, a medication addressing opioid-induced constipation. The company's robust development pipeline includes promising innovations such as flurpiridaz F 18, an agent for assessing myocardial blood flow; 1095, a PSMA-targeted iodine-131 labeled small molecule; LMI 1195 for neuroblastoma tumors in both children and adults; PYLARIFY AI, an AI-powered medical device software for standardized quantitative analysis of PSMA PET/CT images in prostate cancer; and leronlimab, an investigational humanized monoclonal antibody. Lantheus serves a diverse client base, including radiopharmacies, distributors, integrated delivery networks, hospitals, clinics, and group medical practices. They foster strategic collaborations with notable industry partners such as NanoMab Technology Limited, Bausch Health Companies, Inc., GE Healthcare Limited, Curium, Bayer AG, CytoDyn Inc., ROTOP, FUJIFILM, Regeneron Pharmaceuticals, Inc., and POINT Biopharma US Inc. Established in 1956, Lantheus Holdings, Inc. maintains its corporate headquarters in North Billerica, Massachusetts.

Founded1956IPO year2015As of2026-08-04
Market Cap
$6.58B
Enterprise Value
$6.71B
EV / LTM Revenue
4.4x
EV / NTM Revenue
4.3x
Trading multiples

Enterprise value over trailing (LTM) vs. forward (NTM) fundamentals. Click an LTM cell to chart it.

LTM
trailing
NTM
forward
Revenue
4.3x
Gross Profit
7.0x
EBITDA
7.6x
Classification
Sector
Medical Devices & Diagnostics
Sub-sector
Diagnostics & Imaging
Listing
LNTH
Country
US
Historical valuation & fundamentals

EV / LTM Revenue

Annual financials & analyst forecasts

$MCY2021CY2022CY2023CY2024CY2025CY2026ECY2027E
Revenue YoY120%39%18%1%-5%12%
Revenue$425M$935M$1.30B$1.53B$1.54B$1.47B$1.65B
Gross Profit$188M$582M$710M$998M$942M
Gross Profit Margin44.1%62.2%54.7%65.1%61.1%
EBITDA($25M)$82M$491M$515M$404M$823M$925M
EBITDA Margin-5.9%8.8%37.9%33.6%26.2%56.1%56.1%
EBIT($61M)$36M$365M$451M$311M$801M$901M
Net Income($71M)$28M$327M$312M$234M$358M$432M
Free Cash Flow$42M$263M$259M$491M$349M
FCF Margin9.8%28.2%20.0%32.0%22.6%
Short-Term Debt$12M$0.35M$0.82M$0.97M$5M
Long-Term Debt$163M$558M$562M$565M$617M
Cash & Cash Equivalents$99M$416M$714M$913M$359M
Net Debt$76M$142M($151M)($347M)$263M
Net Debt / EBITDA1.7x-0.3x-0.7x0.7x
Rule of 40148.1%58.6%50.3%23.1%
Figures in $M. True calendar years (Jan–Dec) built from quarterly data — income & cash-flow lines summed across the four quarters, balance sheet as of year-end. E columns are calendarized analyst consensus — gross profit, cash flow and balance-sheet lines are not estimated. Net debt = short-term debt + long-term debt − cash & cash equivalents; Rule of 40 = YoY revenue growth + FCF margin.